Welcome to tbtLab!

The Cancer Epigenome research laboratory is focusing on integrated epigenomic and genomic profiling in Asian cancers using enabling technologies such as ChIP-Seq, RNA-seq, Whole-genome and DNA methylation sequencing. The data is then correlated with clinicopathological information including how patients respond to certain drugs. Our research goals are to:

  1. understand the molecular mechanism underlying these cancers;
  2. to identify novel biomarkers than can help determine the nature and behaviour of the disease as well as predicting patients' response to certain drugs; and
  3. to identify novel therapeutic targets with a focus on chromatin enzymes.
The group has hosted and trained clinician scientists, both locally and abroad, who are interested in pursuing translational research. To date, the laboratory has been instrumental in establishing and nurturing several cancer type-based translational research programs at the National Cancer Centre Singapore including biliary tract cancer, lymphoma, sarcoma, breast disease, urological cancer, and peritoneal cancer. The group always emphasizes on collaboration (both local and international) which is key to scientific breakthroughs. The group is now part of the Singapore team that is leading the International Cancer Genome Consortium (ICGC) project on biliary tract cancer. The group is also an integral part of the Lymphoma TCR (Translational Clinical Research) Program.

Professor Bin Tean TEH

Deputy Director (Research), National Cancer Centre Singapore
Deputy Director (Scientific), SingHealth Duke-NUS Institute of Precision Medicine
Professor, Duke-NUS Medical School, Singapore
Senior Principal Investigator, Cancer Science Institute of Singapore
Senior Principal Investigator, Institute of Molecular and Cell Biology, Singapore


Lab News

  • 18 Jan 2018: we are recruiting. Please submit your applications via jobsDB.
  • The Laboratory of Cancer Epigenome is interested in exploring how genetic and epigenetic aberrations drive tumorigenesis. We profile clinical samples to understand disease mechanisms, identify cancer vulnerabilities and develop novel therapeutic interventions. We are seeking for a creative, independent and motivated individual to join our team of cancer biologists, bioinformatics and clinician scientists.

    Positions Descriptions
    Bioinformatician The bioinformatician will report to the manager of Integrated Genomics Platform (IGP) and work closely with IGP team members to provide technical expertise in large-scale-omics data analytics for biological / clinical studies (e.g. setting up customized data processing pipelines for high-throughput sequencing data).

    Your duties include the following:
    • Report to IGP manager to provide technical expertise and provide analytical reports to the clients.
    • Work in the IGP team to provide technical support in clinical and biological data processing, including data quality control, analysis to produce publication-quality analysis.
    • Work closely with the team to assess quality of new sequencing protocols to optimize experimental conditions.

    Job Requirements:
    • M.S. / B.S. in Bioinformatics or related fields (e.g., biostatics, computational biology, computer science).
    • Excellent interpersonal skills, good team player and fast-learner.
    • Excellent analytical, problem-solving and technical skills; detail-oriented.
    • Experiences in next-generation sequencing data processing from data quality control, genomic / epigenomic variation calling, annotation and visualization (e.g., RNA-seq, ChIP-seq, ATAC-seq, etc.).
    • Experiences in R/Python/Perl and familiar with Linux environment.
    • Experiences in handling clinical data is a plus.
    • Experiences in array-based data analysis is a plus, but not a must (e.g., microarray array, methylation array and SNP array).