Principal Investigator

Professor Bin Tean TEH

Deputy Director (Research), National Cancer Centre Singapore
Deputy Director (Scientific), SingHealth Duke-NUS Institute of Precision Medicine
Professor, Duke-NUS Medical School, Singapore
Senior Principal Investigator, Cancer Science Institute of Singapore
Senior Principal Investigator, Institute of Molecular and Cell Biology, Singapore

Dr Bin Tean Teh obtained his MD (1992) from the University of Queensland, Australia and his PhD (1997) from the Karolinska Institute, Sweden.

Following postdoctoral works in multiple endocrine neoplasia 1 at Karolinska Institute, Dr Teh joined the Van Andel Research Institute (VARI) in 2000 as a Senior Scientific Investigator heading the Laboratory of Cancer Genetics. In 2007, Dr Teh was appointed as the founding Director of the National Cancer Centre Singapore (NCCS)-VARI laboratory, which serves as a bridge between translational research and clinical medicine. In 2010 he received the Singapore Translational Research Investigator Award (STaR) award and relocated to Singapore and is currently a full professor in Cancer and Stem Cell Biology (CSCB) Programme at Duke-NUS. He served as the SingHealth Group Director for Translational Research from 2010-2012.

His laboratory focuses on genomic studies of cancers common among Asian populations, using tools such as high-throughput genomic platforms and correlation studies with clinicopathological information.

He holds Adjunct Professorships at several universities worldwide including Baylor College of Medicine, USA, Nanjing University and Sun Yat-Sen University, China and the Karolinska Institute, Sweden.

Dr. Teh has published extensively, with over 350 publications in high impact scientific journals. He has been member of various editorial boards for journals including Lancet Oncology, Cancer Research, Molecular Cancer Therapeutics, International Journal of Oncology, Journal of Clinical Endocrinology and Metabolism, Clinical Genitourinary Cancer, and the American Journal of Translational Research.

Lab Members


Dr Jing TAN, Senior Scientist,

Dr. Tan Jing received his Ph.D. from National University of Singapore in 2012. After 1 year of postdoctoral training in Genome Institute of Singapore, he joined National Cancer Centre Singapore as senior scientist in 2013. He is interested in cancer genomics and cancer therapeutics. Specifically, he focus on genome-wide mapping of the driver mutations in breast fibroepithelial tumors and characterization of the therapeutic activity of JAK3 inhibitors in NK/T cell lymphoma. He has published multiple first-authored papers in Nature Genetics, Cancer Cell, Cancer Discovery and Genes and Development.

Dr Chern Han YONG, Research Fellow,

I have been a part of Prof Teh's lab at Duke-NUS since 2015, working on bioinformatics in cancer genomics and epigenomics. I obtained my Undergraduate and Master's degrees in 1997 and 2004 respectively in Computer Science at the University of Texas at Austin, where I worked on neural networks, genetic algorithms, and the evolution of multi-agent cooperative behavior. From 2005-2008, I worked at the A*Star Institute for Infocomm Research, where I did research on interactive media and a DJ-scratching sound synthesis technology. In 2014 I obtained my PhD in Computational Biology at NUS, where I worked on prediction of protein complexes from high-throughput protein-protein interaction data. In my spare time I enjoy playing music and making noise.

Dr Po-Hung LIN, Research Assistant,

I am a clinician from Dept. Urology of Chang Gung Memorial Hospital, Taiwan. My subspecialty is Uro-oncology. I will attach to Lab of Cancer Epigenome for 22 months (07/2017-04/2019) for basic research. In Taiwan I spent most of the time in clinical works. I have attended to Graduate Institute of Chang Gung University and got the credits, but my hand-on web lab experience is limited. Therefore, I will practice and be familiar to web lab technique and than advance for uro-oncology research.

Dr Ronald Fook Seng LEE, Research Fellow,

I joined the team in 2017 and will be working on the development and application of single cell genomic technologies in the group

Dr Amrita NARGUND, Research Fellow,

Amrita Nargund was born and raised in Mumbai, India. She received her B.Sc (Microbiology) from University of Mumbai, and, M.S. and Ph.D. (Molecular Genetics and Biochemistry) from Georgia State University, USA. She pursued her Post-Doctoral Fellowship in the field of Cell Biology at Memorial Sloan-Kettering Cancer Center in New York, where she studied the mechanism of regulation of mitochondrial unfolded protein response (UPRmt) and how it preserves mitochondrial function during stress by re-routing metabolism (Published: Science, 2012 and Molecular Cell, 2015). She then transitioned into the field of Cancer Biology at MSKCC, where she developed a metabolic cancer (ccRCC) disease mouse model (published: Cell Reports, 2017). Currently, she is in Prof. Bin Tean Teh's lab to study metabolism in ccRCC. In the future, she wants to study the role of mitochondrial health and metabolism in aging and related diseases such as cancer.

Mr Liang Kai KOH, Senior Research Associate,

Liang Kai received his M.Sc. from the National University of Singapore and subsequently joined the group in 2013. He is currently the lab manager for the group's Academia lab, with procurement, grant management and regulatory affairs under his portfolio. Liang Kai also assists with Prof Teh's scheduling and administrative matters.

Mrs Zhimei LI, Senior Research Associate,

Zhimei is primarily responsible for establishment of animal models of different types of carcinoma including SQ, orthotopic, metastasis model treated with interest compounds through different routes and also involved in the in-vitro relevant assays such as cell culture, gene cloning, 3D culture.

Mr Cedric NG, Senior Research Associate,

Exploring innovative & enterprising ideas that are viable & translatable to patient care. I am the team leader in the NGS platform (Integrated Genomics Platform) under the leadership of Prof Teh. Our work deals with unlocking genetic information from archived samples (i.e FFPE from pathology labs) & single cells isolation technologies. These genetic materials are interrogated using current cutting edge NGS techniques generating valuable data.

Mr Peiyong GUAN,

Peiyong received his MSc (Bioinformatics) from Nanyang Technological University and B.Comp (Computer Science, Hons.), minor in Mathematics from National University of Singapore. His research interests center around dissecting the interplays of epigenomics and genomic regulations in oncogenesis, metastasis, and particularly drug resistance.

Mr Hong Lee HENG, Senior Research Officer,

In my current position at the Laboratory of Cancer Epigenome, National Cancer Centre Singapore, I was involved in genome-wide CRISPR knockout screens for targets that are potential as an anti-cancer targets.

Ms Vikneswari RAJASEGARAN, Research Officer,

Part of the Integrated Genomic Platform Team (IGP). Specialises in Next Generation Sequencing & Difficult Samples Preparation such as FFPE, LCM & low input materials.

Miss Giovani Claresta WIJAYA, Research Officer,

I graduated from Faculty of Biotechnology, Atma Jaya Catholic University of Indonesia. During my undergraduate study, I got an opportunity to do my internship at Genome Institute of Singapore for 5 months. I joined Prof Teh's Laboratory since 2013. Since then, I helped my supervisior Dr. Tanjing to do the experiments which focuses on functional study in phylodes tumor, natural Killer T Cell lymphoma, and Renal Carcinoma Cancer. In addition, I trained the internship student to do their experiment.

Mr Yung Ting HSIAO, Research Officer,

I possess a Master's degree in Biology Sciences and Technology from China Medical University at Taiwan, and now I've focus on research during my Ph. D. degree for 4 years. I joined Prof Teh's lab for academic training in 2017, and involved in studying epigenetic changes in renal cell carcinoma.

Miss Gwendolene NG, Research Associate,

I am under the charge of Dr Sim Yirong and also a part of the Integrated Genomic Platform Team. I help out with sample preparation of FFPE tissues for their sequencing on the Next Generation Sequencing platform.

Miss Suet Far WONG, Research Associate,

Member of the Integrated Genomics Platform (IGP) team. Assisting in Next Generation Sequencing (NGS) and Nanostrings work.

Miss Jing Yi LEE, Research Assistant,

Completed her BSc (Biomedical Science) in Griffith University, Australia in December 2016. She joined the team in May 2017 after interning there for 2 months. Her main roles include assisting Dr Huang Dachuan with his renal cell carcinoma and sarcoma projects.


Dr Li Mei NG, Research Fellow,

Dr Ng obtained her PhD (2013) from the National University of Singapore. Her doctoral research, performed under reknowned structural biologist Dr Eric Xu (Distinguished Director of VARI-SIMM Research Center), provided structural and mechanistic evidence which unraveled the long-standing scientific mystery of the identity of abscisic acid receptors. Her structural studies of the entire core abscisic acid signaling pathway has been published in top journals including Nature and Science and featured as one of top 10 Breakthroughs of 2009 by Science, one of Top 10 Signaling Breakthroughs by Science Signaling and Research Highlights by Nature Cell Biology. Dr Ng joined Cancer Science Institute of Singapore as a Research Fellow in 2013 to set up a new lab under PI Prof Teh Bin Tean. Her current interest is in the molecular and structural studies of cancer-associated proteins using X-ray crystallography and biochemical/biophysical methods and the development of efficient protein expression/studies techniques.

Dr Po-Hsien LEE, Research Fellow,

My research interest is to study structural and functional properties of biomolecules by computational approaches. During my PhD years, I developed software toolkits to detect pockets inside protein structures and to predict pore-lining residues of alpha-helical transmembrane proteins. I also performed Brownian Dynamics simulation to estimate the protein permeation rate through nanopores. In Prof. Teh’s research group, I closely cooperate with Dr. Ley Moy Ng who is an expert of X-ray crystallography. We adopt computational and experimental techniques to screen compounds for nuclear receptors that involve in tumorigenesis of breast cancer. An in silico high-throughput virtual screening pipeline is built for potential ligands of nuclear receptors. Biomedical assays such as thermal-shift assay, reporter assay and mammalian 2-hybrid assay are conducted to validate computational suggestions.

Dr Mun Juinn CHOW, Research Fellow,

Mun Juinn obtained his B.Sc.(Hons) 1st Class in Chemistry in 2011 and his PhD in 2015, both from the National University Singapore. During his PhD and first Postdoc, he managed several multidisciplinary research projects, working closely with both Chemists and Molecular Biologists in the development of anticancer drug discovery platforms and the elucidation of drug candidate mode-of-action by integrating chemical synthesis, structure-activity relationship, biochemical and molecular biological studies. He is passionate about cancer research, particularly in drug-resistant cancer treatment strategies and is currently the "in-house chemist" in Prof Teh Bin Tean's Lab, working on target-based drug discovery and isogenic cell lines generation for drug efficacy studies. Outside the lab, Mun Juinn is an avid guitarist/singer and self-professed foodie.

Ms Aisyah BASHIR, Research Officer,

I have started off my first career in CSI under Professor Teh's lab upon graduation from NTU with my Hons in Biological Sciences. I believe that I would be able to bring value to the research team through my knowledge and also gain valuable experience and skills throughout my journey here.


Dr Xiaosai YAO, Research Fellow,

Xiaosai is studying epigenetic changes in kidney cancer samples, as a result of driver mutations. She previously worked on circulating tumor cells at MIT for her graduate work.

Dr Jing Han HONG, Research Fellow,

Jing Han joined Prof Teh's lab in 2017. She is involved in studying epigenetic changes in renal cell carcinoma.

Miss Michelle NG, Research Officer,

I'm working in IMCB as a research officer for Dr Yao Xiaosai.



Dr Choon Kiat ONG, Senior Scientist,

I joined Prof Teh's laboratory as a Research Fellow in 2007 and left in 2015 as a Senior Scientist. I was involved in assisting the PI in operation and management of the laboratory where we grew from a small group of 3 staffs to a strong research team of about 20 staffs. Scientifically, I was one of the scientists leading the genomic research for cholangiocarcinoma and breast fibroepithelial tumor. Currently, I am the principal investigator leading the Lymphoma Genomic Translational Research Laboratory at the National Cancer Centre Singapore.

Dr Song Ling POON, Senior Research Fellow,

Dr. Song Ling Poon received her Ph.D. degree from the University of British Columbia in Canada. Subsequently, she joined National Cancer Centre Singapore to conduct her postdoctoral training in translational research. Her principal research interests circumscribe the topic of genetic instability in cancer cells. She seeks to utilize next generation sequencing in conjunction with high throughput screening to elucidate the roles of aberrant signaling pathways in cancer cell biology for the development of cancer therapeutics. She has published widely in leading journals including Nature Genetics, Science Translational Medicine, and Cancer Discovery. Currently, Dr. Poon is the project manager and medical scientific liaison of ACT Genomics.

Dr Maarja-Liisa NAIRISMÄGI, Research Fellow,

Dr. Maarja-Liisa Nairismägi obtained her PhD in Molecular Biology in 2011 from Aarhus University, Denmark. As a research fellow in Prof. Bin Tean Teh's lab she studied the genomics of solid cancers such as cholangiocarcinoma and pancreatic cancer, and performed functional experiments. She took over the management of all lymphoma projects in the lab and subsequently contributed to the founding of the Lymphoma Genomic Translational Research Laboratory in National Cancer Centre Singapore where she is currently a Research Fellow.

Dr Apinya JUSAKUL, Research Fellow,

Apinya was a research fellow in the Department of Cancer and Stem Cell Biology, Duke-NUS medical school. Her work focuses specially on the genomic and epigenomic profiling in biliary tract cancers including cholangiocarinoma and gallbladder cancer. She is now a faculty member of the Department of Immunology and Blood Bank, Faculty of Associated Medical Science, Khon Kaen University, Thailand.

Dr Dachuan HUANG, Senior Research Fellow,

Dr. Huang received his Ph.D. from National University of Singapore. His work focused on translational cancer research in renal cell carcinoma and sarcoma.

Dr Jing Quan LIM, Research Fellow,

Managed the bioinformatics wing of the team. With a general interest in translational and precision medicine.

Dr Pauline ONG, Research Fellow,

High throughput screening including both arrayed screening and pooled screening.

Ms Yurike LAURENSIA, Research Officer

I received my bachelor degree from Atma Jaya Catholic University where I studied Biotechnology. I did a short-term internship in Genome Institute of Singapore, A-star, before I started to work in Prof Teh's lab. I worked as Research Officer that helped my supervisor, Dr Maarja-Liisa Nairismagi, who focused her attention in lymphoma research. A year after that, I was shifted into Lymphoma Genomic Translational Research Laboratory, that is led by Dr Ong Choon Kiat, which is my current lab now. In this lab, I still help Dr Maarja-Liisa Nairismagi to do some experiment in genomic and functional study to seek understanding in several subtypes of T-cell lymphoma. Some of the works that I do are Sanger sequencing, Targeted Sequencing, Cloning, and etc. I also help to maintain stock levels of laboratory supplies and facilitate weekly lab meeting.

Ms Ee Yan SIEW, Research Officer

Siew Ee Yan was a research officer who worked extensively on the in vivo studies of the laboratory. Her work at NCCS contributed to the publication of several scientific papers by the laboratory. She also supported the day-to-day running of the laboratory. Ee Yan graduated with B.Sc (Hons) from Murdoch University in 2014.

Mr Jia Liang LOH, Research Officer

I was in charge of collecting, cataloging and managing patient samples and data, and subsequent DNA & RNA extraction and distribution for downstream work.

Miss Joanna KOH, Research Officer

I joined academic research since I graduated from Ngee Ann Poly and moved on to further my studies in 2017. My time here had helped me realise that cancer research is very interesting as it helped me achieve my goal of making a difference in people's lives! My role in the lab was to assist researchers in running their wet lab experiments. I hope to eventually be able to take ownership of my own project!

Ms Meina LAU, Research Officer

Meina was the Laboratory Executive of Prof Teh's lab at Cancer Science Institute (CSI), NUS. She was involved in carrying out experiments, lab management as well as the training of students.

Ms Wan Lu Jane PANG, Research Officer,

I was assisting my PI, Dr. Ong Choon Kiat, in various research projects as well as laboratory management and administration. We studied mainly T-cell and NK-cells lymphoma in vitro and in vivo. My primary role was to establish and maintain patient-derived xenograft (PDX) mouse models. These PDX models were used in our in vivo drug treatment experiments.

Miss Swe Swe MYINT, Senior Research Officer,

Collecting patient tissue samples and blood of all the projects, Cataloging, storage and organize information, Extraction of DNA, RNA from patient tissue samples, Handling IRB renewal for tissue collection.

Ms Sanjanaa NAGARAJAN, Research Associate,

Sanjanaa was a part of the bioinformatics team. She received her MSc (Bioinformatics) from Nanyang Technological University. Her work involved data analysis of high throughput sequencing data, copynumber data and synthetic lethality studies.